Detrol La (Tolterodine Tartrate)

Detrol La Review

Detrol LA capsules are once daily extended release capsules indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

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Detrol La Drug Class and Mechanism

Tolterodine acts on M2 and M3 subtypes of muscarinic receptors whereas most antimuscarinic treatments for overactive bladder only act on M3 receptors making them more selective. Tolterodine, although it acts on two types of receptors, has fewer side effects than other antimuscarinics eg. oxybutynin (which is selective for M3 only) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are fewer side effects.

Detrol La Uses

Take Detrol tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If you are taking the extended-release capsules, swallow them whole, do not crush, cut, or chew. Take your doses at regular intervals. Do not take Detrol more often than directed. Do not stop taking except on your doctor's advice. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Detrol La Side Effects

Serious side effects are not common. Side effects that you should report to your doctor as soon as possible: any signs of an allergic reaction, like itching or hives; blurred vision or difficulty focusing vision; confusion; difficulty passing urine; severe dizziness. Side effects that usually do not require medical attention (report to your doctor if they continue or are bothersome): constipation; dry eyes; dry mouth; headache; mild dizziness or drowsiness; indigestion or stomach discomfort.

Detrol La Pregnancy

Pregnancy Category C. At oral doses of 20 mg/kg/day (approximately 14 times the human exposure), no anomalies or malformations were observed in mice. When given at doses of 30 to 40 mg/kg/day, tolterodine has been shown to be embryolethal and reduce fetal weight, and increase the incidence of fetal abnormalities (cleft palate, digital abnormalities, intra-abdominal hemorrhage, and various skeletal abnormalities, primarily reduced ossification) in mice. At these doses, the AUC values were about 20- to 25-fold higher than in humans. Rabbits treated subcutaneously at a dose of 0.8 mg/kg/day achieved an AUC of 100 µg·h/L, which is about 3-fold higher than that resulting from the human dose. This dose did not result in any embryotoxicity or teratogenicity. There are no studies of tolterodine in pregnant women. Therefore, DETROL LA should be used during pregnancy only if the potential benefit for the mother justifies the potential risk to the fetus

Detrol La Overdose

A 27-month-old child who ingested 5 to 7 tolterodine immediate release tablets 2 mg was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. The child fully recovered. Management of Overdosage Overdosage with DETROL LA Capsules can potentially result in severe central anticholinergic effects and should be treated accordingly. ECG monitoring is recommended in the event of overdosage. In dogs, changes in the QT interval (slight prolongation of 10% to 20%) were observed at a suprapharmacologic dose of 4.5 mg/kg, which is about 68 times higher than the recommended human dose. In clinical trials of normal volunteers and patients, QT interval prolongation was observed with tolterodine immediate release at doses up to 8 mg (4 mg bid) and higher doses were not evaluated

Detrol La More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Detrol LA may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Detrol LA. Avoid becoming overheated in hot weather. Detrol LA may increase the risk of heat stroke because it may decrease sweating. Drink plenty of fluid to maintain adequate hydration.